Mammalian Display
When a target needs human-like glycosylation or full-length IgG context, mammalian display on CHO and HEK293 earns its cost. The methods behind that call.
Working on a mammalian display project? See our mammalian display services.
mammalian display services →Full-Length IgG Display on Mammalian Cells
Why screening full-length IgG on mammalian display beats reformatting scFv hits: native chain pairing, Fc glycosylation, and developability in the final format.
When to Choose Mammalian Over Yeast Display
A decision guide for mammalian display vs yeast display: glycan-dependent epitopes, full-length IgG, membrane targets, and production-context developability.
Glycoprotein Engineering: Yeast Can't Do This, Mammalian Can
Glycoprotein engineering requires mammalian PTM machinery. When to skip yeast display and go straight to CHO/HEK293.
Mammalian Cell Display: When CHO and HEK293 Outperform Yeast
CHO and HEK293 mammalian display platforms preserve PTMs and disulfide bonds that yeast display cannot. When to use which.
Mammalian Cell Engineering: From Stable Line to Functional Assay
Mammalian cell engineering services for stable cell lines, knockouts, knock-ins, reporter cells, and high-throughput functional assays.
Phage Display vs Yeast Display: When to Choose Which Platform
Phage display, yeast display, and mammalian display each fit different campaigns. A practical decision framework for choosing the right platform.
The Two-Platform Approach: Using Yeast Display for Affinity and Mammalian Display for Developability
Don't choose between yeast display and mammalian display. This guide details a two-platform biologics discovery workflow, using yeast for affinity and mammalian display to screen for developability.
Post-Translational Modifications in Mammalian Protein Production
Post-translational modifications are a fundamental layer of biological regulation that dictates a protein's function and viability as a drug. Understanding glycosylation, disulfide bonds, and chemical liabilities.
Troubleshooting Low Display Levels in Yeast and Mammalian Cells
Low or non-existent display levels are a common roadblock in yeast and mammalian display campaigns. A systematic diagnostic checklist for identifying and resolving the root cause.
Titrating Display Levels for Reliable Affinity Data
Learn how to optimize display-level titration in yeast and mammalian display systems to obtain accurate affinity data and avoid avidity effects when determining Kd.
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