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Leader in Protein Engineering Services & CRO Solutions
Partner with a world-class protein engineering company dedicated to accelerating your R&D. Our comprehensive protein engineering CRO solutions provide the scale and precision needed to overcome limitations in protein function, stability, and expression. From library design to candidate selection, we offer specialized protein engineering services that transform complex biological challenges into high-performance results
End-to-End Protein Engineering Services for Global Biopharma
As a premier protein engineering company, we help you overcome fundamental limitations in protein function, stability, and expression. Our protein engineering CRO model leverages high-throughput screening and massive combinatorial libraries to deliver:
Precision Engineering: Identify candidates with the exact characteristics your research demands.
Unparalleled Scale: Explore vast protein design spaces using powerful pooled screening.
Accelerated Timelines: Specialized protein engineering services designed to move your project from library design to lead candidate faster.
Comprehensive Protein Engineering Services
Utilize our robust yeast cell surface display and mammalian cell surface display for protein engineering of antibodies and scaffolds. Ensure your variants maintain improved stability and affinity within a native eukaryotic context
We offer a comprehensive suite of services to build and screen for better proteins, faster.
Deep Mutational Scanning
Systematically map the functional consequences of every possible amino acid substitution. Our protein engineering services include generating comprehensive fitness landscapes to guide rational design and identify functional hotspots with unparalleled data depth
Custom Combinatorial Libraries
"Go beyond single mutations. We construct and screen vast combinatorial libraries to capture synergistic mutations—a core deliverable of our protein engineering CRO solutions. This scale allows us to achieve improvements that are impossible through standard, low-throughput methods
Site-Directed Mutagenesis
Precisely introduce targeted mutations to test hypotheses or create specific protein variants. Our protein engineering services leverage structural data to validate functional sites, ensuring your project is grounded in rigorous molecular accuracy.
Functional Assays
Directed Evolution
Develop and execute robust, high-throughput cell-based and in vitro enzyme assays. Our role as your protein engineering CRO is to provide the critical functional data needed to identify and validate successful candidates for your pipeline
Design and execute pooled screening assays to identify better-performing protein variants at scale. Through iterative rounds of selection, our protein engineering services mimic natural evolution to optimize your proteins for real-world industrial or therapeutic applications
Protein Engineering Trusted by 100+ Leading Biotechnology Companies and Insitutions
★★★★★
Frequently asked questions
Why should I partner with an external protein engineering company?
Partnering with a dedicated protein engineering company allows your team to access "design-space" exploration that is often cost-prohibitive to build in-house. We provide the massive scale of combinatorial libraries and the proprietary screening platforms necessary to identify rare variants with superior function, stability, or expression profiles.
What type of protein engineering services do you offer?
We provide a comprehensive suite of protein engineering services, including:
Deep Mutational Scanning: Comprehensive mapping of protein fitness.
Directed Evolution: Iterative selection for optimized traits.
Display Technologies: Yeast and mammalian display for eukaryotic protein optimization.
Custom Library Construction: High-fidelity combinatorial libraries for screening millions of variants.
How does your CRO handle intellectual property (IP)?
As a client-focused protein engineering CRO, we typically operate under a fee-for-service model where the resulting data and optimized sequences belong to the client. We understand the sensitive nature of protein scaffolds and ensure strict confidentiality and IP protection throughout the project lifecycle.
Can you optimize proteins for specific industrial conditions?
Yes. Our protein engineering services are frequently used to improve enzyme performance under extreme conditions, such as specific pH levels, high temperatures, or in the presence of organic solvents. By mimicking natural selection at an accelerated pace, we can "evolve" proteins to meet your exact industrial specifications.
How does your protein engineering company handle "difficult-to-express" proteins?
Many clients come to us after internal efforts with traditional methods fail. As a specialized protein engineering company, we utilize eukaryotic display systems (Yeast and Mammalian) that provide the necessary post-translational modifications for complex proteins. By combining this with our high-throughput screening, we can evolve variants specifically for higher expression titers without sacrificing biological activity or structural integrity.
How do your protein engineering services differ from purely computational (AI) approaches?
While AI-driven design is a powerful tool, it often requires high-quality experimental data to be effective. Our protein engineering services provide the "wet-lab" validation and data generation that complement AI models. We can screen millions of physical variants through Deep Mutational Scanning, providing functional validation that complement AI approaches.
Can your CRO assist with antibody affinity maturation and humanization?
Absolutely. Affinity maturation is one of our core protein engineering services. By generating targeted combinatorial libraries around the CDR regions and using display technologies, we can increase binding affinity by 10-fold to 100-fold. Our platform also allows for "soft" randomization during humanization to maintain stability while reducing potential immunogenicity.
What data deliverables should I expect from a protein engineering CRO partnership?
We believe in data transparency. When you engage our protein engineering services, you receive comprehensive reports including NGS data from library selections, enrichment plots, characterization data for top-performing variants, activity assays data, and the physical clones for your lead candidates.
Get in touch
Partner with a Leading Protein Engineering Service Team
Ready to accelerate your research with specialized protein engineering services? Whether you are looking for a long-term protein engineering CRO partner or need a custom combinatorial library for a specific target, our team is ready to help. Fill out the form below to schedule a technical consultation and discover how our platform can scale your protein design efforts.