Yeast Display Services for Antibody Discovery & Protein Engineering

The Core Challenge in Antibody Discovery: Finding the Best Candidate

The success of any therapeutic antibody discovery program hinges on identifying rare variants with superior function. However, the sheer scale of modern libraries creates significant challenges for traditional methods:

Vast Libraires

Effectively screening billions of unique variants to find the top 0.001% is a major logistical bottleneck in antibody discovery

Subtle Differences

Distinguishing between candidates with minor but critical differences in affinity and specificity requires highly quantitative techniques

Slow, manual screening methods can delay the entire antibody discovery process, increasing costs and time to clinic

Project Timeline

Without an efficient, high-throughput solution, promising candidates are often missed, putting entire project at risk.

A Validated Yeast Display Platform for Modern Antibody Discovery

Massive Library Screening

A core capability for antibody discovery, we screen libraries of up to 1 x 10⁹ variants.

Quantiative FACS Sorting

Our yeast display process allows for precise, quantitative sorting based on subtle differences in binding affinity, kinetics, and expression.

Multi-Parameter Selection

Go beyond simple binding to screen for complex functional profiles relevant to your therapeutic goals.

Accelerated Discovery

Condense months of screening into weeks, delivering better candidates for your antibody discovery pipeline, faster.

Ranomics' Yeast Display platform is a powerful engine for modern antibody discovery. By expressing vast libraries on the surface of yeast cells, we leverage quantitative fluorescence-activated cell sorting (FACS) to analyze and enrich for proteins with superior characteristics.

This yeast display workflow provides a direct link between a protein's function (like binding affinity) and a fluorescent signal, allowing for the precise isolation of top-performing variants and transforming a slow process into a rapid, scalable antibody discovery engine.

Yeast Display Applications in Antibody Discovery and Beyond

Our versatile yeast display platform is a cornerstone of successful protein engineering and antibody discovery campaigns:

• Antibody Discovery & Affinity Maturation: Isolate novel, high-affinity monoclonal antibodies, scFvs, and nanobodies from diverse synthetic or immune libraries.

• Epitope Mapping: Precisely define the binding sites of your antibodies on a target antigen.

• Enzyme Optimization: Screen for variants with enhanced catalytic activity.

• Early Developability Screening: Select for antibody variants that exhibit high expression and stability, de-risking downstream development.

Case Study Highlight

Accelerate Your Antibody Discovery Program with Yeast Display

Don't let screening be the bottleneck in your pipeline. Leverage the speed, scale, and precision of Ranomics' Yeast Display platform to identify superior biologic candidates and advance your antibody discovery program.