Genetic variants close in promixity to exon-intron junctions have a high chance of perturbing gene function, which could result in disease causation.

 

To rapidly identify genetic variants that may disrupt splicing, Ranomics has developed a dual-fluorescence based reporter that is compatible with any exon-intron-exon junction of interest. 

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Our reporter system is compatible with a variety of readouts:

 

• microscopy 

• fluorescence-activated cell sorting

• next generation sequencing

 

Ranomics' splicing reporter system can be adapted to characterize a single variant or thousands of variants in a single, streamlined workflow.