Splicing variant analysis
Genetic variants close in promixity to exon-intron junctions have a high chance of perturbing gene function, which could result in disease causation.
To rapidly identify genetic variants that may disrupt splicing, Ranomics has developed a dual-fluorescence based reporter that is compatible with any exon-intron-exon junction of interest.
Our reporter system is compatible with a variety of readouts:
fluorescence-activated cell sorting
next generation sequencing
Ranomics' splicing reporter system can be adapted to characterize a single variant or thousands of variants in a single, streamlined workflow.